En passant

Cardiotoxicity is one of the main adverse effects of the anti-cancer drugs, affecting the completion of treatment and both short-term and long-term quality of life. Cardio-oncology is an emerging medical field involved in prevention, detection, and treatment of cardiovascular effects from cancer therapy.

Our lab, which is part of the European ERA-NET consortium in Cardio-Oncology, combines medicinal chemistry, molecular and cellular biology and pharmacology to address the following objectives:                                                                                             – 1- to develop new cardioprotective non-peptide agonists of prokineticin receptor 1 (PKR1),                                                                                                                                    – 2- to discover novel prohibitins ligands and inhibitors of the initiation factor of translation eIF4A for the treatment of heart diseases and cancers,                                                         – 3- to develop of novel diagnostic tools for cardiotoxicity,                                                       – 4- to identify the molecular and cellular mechanisms controlling cardiac myogenesis, neovasculogenesis, and adipogenesis in hearts injured by anticancer drugs (anthracyclines, cisplatin, etc.).

The biological and medicinal chemistry studies are respectively supervised by Dr Canan Nebigil at the Higher School of Biotechnology (ESBS) of Strasbourg, and Dr Laurent Désaubry at Le Bel Institute of the University of Strasbourg.

Contacts

Dr Canan Nebigil, CNRS Research Director                                                                         Laboratoire de Cardio-Oncologie et Chimie Médicinale                                                   Ecole Supérieure de Biotechnologie de Strasbourg                                                       Boulevard Sébastien Brandt, BP10413
67412 Illkirch CEDEX, France
Phone : (+33) 368 854 756
mail : nebigil@unistra.fr

Dr Laurent Désaubry, CNRS Research Director                                                                 Laboratoire de Cardio-Oncologie et Chimie Médicinale                                                    Institut Le Bel                                                                                                                           4 rue Blaise Pascal, CS 90032                                                                                        67081 Strasbourg, France                                                                                                    Phone : (+33) 368 851 606
mail : desaubry@unistra.fr