Miscellaneous

Discovery of iminobenzimidazole derivatives as novel cytotoxic agents. Chouha N., Hammoud H., Brogi S., Campiani G., Welsch C., Robert C., Vagner S., Cresteil T., Bentouhami E., Désaubry L. Open Med. Chem. J. 12: 74-83 (2018).

Discovery of GPCR ligands for probing signal transduction pathways. Brogi S.,Tafi A., Désaubry L., Nebigil-Désaubry C.G. Front. Pharmacol. 5: 255 (2014).

Cancer wars: Natural products strike back. Basmadjian, C.; Zhao, Q.; Djehal, A.; Bentouhami, E.; Nebigil, CG.; Johnson, RA., Serova, M.; de Gramont, A.; Faivre, S.; Raymond, E.; Désaubry, L. Frontiers Chem. 2, article 20 (2014).

Benzofuran derivatives as anticancer inhibitors of mTOR signaling. Salomé C, Ribeiro N, Chavagnan T, Thuaud F, Serova M, de Gramont A, Faivre S, Raymond E, Désaubry L. Eur J. Med. Chem. 74: 181–191 (2014).

Benzofuran derivatives as a novel class of inhibitors of mTOR signaling. Salomé C, Ribeiro N, Narbone V, Thuaud F, Serova M, de Gramont A, Faivre S, Raymond E, Désaubry L. Eur J. Med. Chem. 74: 41–49 (2014).

Cytochromes P450 CYP94C1 and CYP94B3 catalyze two successive oxidation steps of plant hormone Jasmonoyl-isoleucine for catabolic turnover. Heitz T, Widemann E, Lugan R, Miesch L, Ullmann P, Désaubry L, Holder E, Grausem B, Kandel S, Miesch M, Werck-Reichhart D, Pinot F. J Biol Chem. 287: 6296-306 (2012).

Biomimetic Synthesis and Properties of Polyprenoids. Ribeiro N., Gotoh M., Nakatani Y., Désaubry L. in Biomimetics, InTech, Ed. Lilyana D. Pramatarova, p 195-212 (2011).

Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. Polier G, Ding J, Konkimalla BV, Eick D, Ribeiro N, Köhler R, Giaisi M, Efferth T, Désaubry L, Krammer PH, Li-Weber M. Cell. Death Dis. 2: e182 (2011).Synthesis and biological evaluation of PEG-tirofiban conjugates. Désaubry L., Riché S., Laeuffer P., Cazenave J-P. Bioorg. Med. Chem. Lett. 18: 2028–31 (2008).

Synthesis of 3-O-methylviridicatin analogues with improved anti-TNF-α properties. Ribeiro N., Tabaka H., Peluso J., Fetzer L., Nebigil C., Dumont S., Muller C.D., Désaubry L. Bioorg. Med. Chem. Lett. 17: 5523-4. (2007).

Adenine nucleoside-3′-tetraphosphates are novel and potent inhibitors of adenylyl cyclase. Désaubry L., Johnson R.A. J. Biol.Chem. 273, 24972-24977 (1998).